Four women have groundbreaking two-in-one surgery to reduce their risk of ovarian cancer while undergoing a C-section

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  • The 4 women were all  astatine higher consequence of nan illness owed to cistron alterations

By Xantha Leatham Deputy Science Editor

Published: 21:53 EDT, 2 November 2023 | Updated: 21:57 EDT, 2 November 2023

Four women person had groundbreaking two-in-one room to trim their consequence of ovarian cancer while undergoing a caesarean section.

The women, who were treated astatine University College London Hospitals (UCLH), were each carriers of nan BRCA1 aliases BRCA2 cistron alterations which put them astatine higher consequence of nan disease.

Surgery to trim nan consequence for these patients is usually a standalone process to region nan Fallopian tubes and ovaries. But experts decided to spot if it could beryllium done successful conjunction pinch a C-section.

The first two-in-one room was carried retired successful 2018, while 3 much person been completed since. 

Scientists opportunity that, fixed its success, it could routinely beryllium offered to women who are astatine higher consequence of ovarian crab and who are owed to person a C-section. 

Claire Rodrigues Lee, 45, was 1 of nan 4 women to person a groundbreaking two-in-one room to trim their consequence of ovarian crab while undergoing a caesarean section

The women, who were treated astatine University College London Hospitals (pictured), were each carriers of nan BRCA1 aliases BRCA2 cistron alterations which put them astatine higher consequence of nan disease

Case Study: Claire Rodrigues Lee

Claire Rodrigues Lee, 45, from London, was 1 of nan 4 women to person nan surgery. She had it successful 2019 astatine nan aforesaid clip arsenic nan commencement of her boy - her 2nd child.

She said: ‘As a bearer of nan BRCA2 cistron alteration, I knew I was astatine higher consequence of ovarian crab and I wanted to person nan risk-reducing room arsenic soon arsenic imaginable aft giving commencement for nan 2nd time.

‘I was looking up online really quickly I could person nan room aft giving birth, and I came crossed nan mixed surgery, arsenic nan first lawsuit had conscionable been done, truthful I wanted to cognize if it would beryllium imaginable for me.

‘At that constituent I made interaction pinch nan squad astatine UCLH who performed nan room - and yet made plans to person nan mixed room there. I americium gladsome I did, and it meant that I didn’t request to spell backmost into infirmary for room aft giving birth.

‘Recovery was nary different having mixed room to conscionable having a C-section - my first kid was calved via C-section truthful I knew what to expect.

Women who transportation these cistron alterations - including character Angelina Jolie - person an 11-68 per cent life consequence of processing ovarian crab compared pinch a 2 per cent consequence successful nan wide population.

BRCA cistron alterations are linked to astir 15 per cent of ovarian cancers.

Risk-reducing room is nan only proven measurement to trim ovarian crab mortality and it slashes nan consequence of nan illness by astatine slightest 95 per cent.

All 4 women, who were betwixt 40 and 45 years old, were referred to UCLH while they were pregnant betwixt 2018 and 2022. They were each owed to springiness commencement by C-section and were not readying to person immoderate further children.

The patients did not request to enactment successful infirmary immoderate longer than they would person aft a C-section alone, and nary had superior complications.

Professor Adam Rosenthal, a advisor gynaecologist astatine UCLH, said: 'Offering this two-in-one room could beryllium very beneficial to different women astatine precocious consequence of ovarian cancer, who would past debar nan request for abstracted risk-reducing surgery.

'The number of women who springiness commencement by caesarean conception is expanding astir nan world, arsenic is nan number of women who cognize they transportation a cistron alteration which increases their ovarian crab risk.

'This intends galore much women whitethorn beryllium suitable for nan mixed procedure. There is besides a imaginable costs redeeming to immoderate healthcare strategy by avoiding nan request for 2 abstracted operations.'

Both men and women tin person faulty BRCA1 and BRCA2 genes and, according to Cancer Research UK, they are recovered successful astir 1 successful 400 people. 

Those who inherit faulty versions of these genes person an accrued consequence of processing nan ovarian, breast, prostate and pancreatic strains of cancer.

The 4 cases were reported successful nan Journal of Obstetrics and Gynaecology.


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